The notion of hybridity is a theme that runs through many of Djibril Diop Mambéty films. Like many of his contemporaries, Djibril Diop Mambéty used the cinematic medium to comment on political and social conditions in Africa. As critiques of neocolonialism, like those of Ousmane Sembène and Souleymane Cissé, Mambéty's films can similarly be understood in the context of Third Cinema. Yet, his often unconventional, surrealist, fast-paced, non-linear style distinguishes Mambéty from other prominent filmmakers of Francophone African Cinema who employed more traditional didactic, social realist narratives. African Studies scholar Sheila Petty notes, "unlike other African filmmakers of the late 1960s and early 1970s whose films were structured around essentialist nationalist discourse focused on the binary opposition of African values versus cultural alienation, Mambéty sought to expose the diversity of real life"  According to critics like Petty, his films were an expression of an African sensibility neither locked into narrow nationalism nor into colonial French culture. Instead of rejecting or elevating one as more or less authentically African, Mambéty confronted and engaged with postindependent Africa's complexities and contradictions. Montage sequences in his films that are overflowing with symbols and sounds of traditional and modern Africa, as well as contemporary European culture, depict hybridity. In addition, his own editing and narrative style are a confluence of the ancient griotic tradition of tribal storytelling and modern avant-garde techniques. Mambéty was interested in transforming conflicting, mixed elements into a usable African culture, and in his words, "reinventing cinema"
 
Other common thematic concerns in Mambéty's films are power, wealth and delusion. Offering a cynical view of humanity in his last feature-length film, Hyènes, Mambéty implicates Africans themselves for a continuing dependency on the West. Through the film and in many interviews, the director suggests that Africans are short-sighted in looking to the colonial past for their future, and are misled by their unrestrained desires for material goods that ensure Africa's dependency on foreign aid. Ultimately, however, Mambéty transmitted a message of hopefulness in his final films, which elevate the "little people," as the bearers of a positive and new Africa. "The only truly consistent, unaffected people in the world," Mambéty once said of the marginalized, "for whom every morning brings the same question: how to preserve what is essential to themselves"